ANNEX I. SUMMARY OF PRODUCT CHARACTERISTICS. 1 INTEGRILIN is indicated for the prevention of early myocardial infarction in adults presenting. Package leaflet: Information for the patient. Integrilin mg/ml solution for infusion eptifibatide. Read all of this leaflet carefully before you start using this. 1. Package leaflet: Information for the patient. Eptifibatide Accord 2 mg/ml solution for injection eptifibatide. Read all of this leaflet carefully before you start using.
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The development of antibodies to eptifibatide at higher doses has not been evaluated. There was no apparent difference in efficacy between older and younger patients treated with Packahe Injection. These findings suggest acute thrombocytopenia after the administration of Integrilin can develop inteyrilin a result of naturally occurring drug-dependent antibodies or those integtilin by prior exposure to Integrilin.
Prevention of acute reocclusion after thrombolysis with IV recombinant tissue plasminogen activator. This was a “real world” study; each patient was managed according to the usual standards of the investigational site; frequencies of angiography, PCI, and CABG therefore differed widely from site to site and from country to country.
As shown in Table 7, each eptifibatide regimen reduced the rate of death, MI, or urgent intervention, although at 30 days, this finding was statistically significant only in the lower-dose eptifibatide group. The majority of patients received aspirin mg once daily.
Heparin sodium injection prescribing information.
Eli Lilly and Company. Patients Abrupt Closure 65 5.
Used in conjunction with aspirin and heparin in clinical studies. Safety and efficacy inseet abciximab combined with dalteparin in the treatment of acute coronary syndromes. If a patient with low platelet counts is receiving Eptifibatide Injection, their platelet count should be monitored closely.
Administer by IV injection followed by IV infusion using a controlled-infusion device e. The need for thrombotic “bailout” was significantly reduced with Integrilin at 48 hours 2. Patients in clinical studies were older range: This difference may be a true treatment difference, the effect of other differences in these subgroups, or a statistical anomaly.
Safety and efficacy of eptifibatide therapy in patients with previous stroke or transient ischemic attack. The development of antibodies to eptifibatide at higher doses has not been evaluated. As shown in Table inhegrilin, the incidence of the primary endpoint and selected secondary endpoints was significantly paxkage in patients who received Integrilin. Among patients experiencing a major bleed in the EMPACT II study, an increase in bleeding on Eptifibatide Injection versus placebo was observed only for the femoral artery access site 3.
Eptifibatide Injection – FDA prescribing information, side effects and uses
Use with caution 1 4 34 43 Heparin sodium during medical management: Results of a Veterans Administration Cooperative Study. In these studies, Integrilin inhibited ex vivo platelet aggregation induced by adenosine diphosphate ADP and other agonists in a dose- and concentration-dependent manner.
When obtaining intravenous access, avoid non-compressible sites e. Twelve-month clinical event data were available for patients on eptifibatiderepresenting Dosage of integfilin required to maintain an appropriate activated clotting time ACT during concomitant therapy with eptifibatide may be lower than with heparin monotherapy.
Targeted approaches to thrombus formation: Patients Overall incidence of major bleeding 9. Table 6 shows the incidence of death or MI within 72 hours. After PCI, Eptifibatide integrilun should be continued until hospital discharge or up to 18 to 24 hours, whichever comes first. Manufacturer recommends — mg 1—24 hours prior to PCI and daily thereafter.
Patients in clinical studies were older range: Randomised placebo-controlled trial of effect of eptifibatide on complication of percutaneous coronary intervention: Because animal reproduction studies are not always predictive of human response, Integrilin should pqckage used during pregnancy only if clearly needed. Available for Android and iOS devices.
The infusion was continued integrliin 72 hours, until hospital discharge, or until the time of CABG, whichever occurred first, except that if PCI was performed, the Integrilin infusion was continued for 24 hours after the procedure, allowing for a duration of infusion up to 96 hours.
Handbook on injectable drugs.
Integrilin Monograph for Professionals –
We comply with the HONcode standard for trustworthy integriliin information – verify here. Inhibition of platelet aggregation 15 min after bolus. Instructions for Administration 1.