FORMULATION AND EVALUATION OF MEDICATED CHEWING GUM PDF

Abstract: The medicated chewing gum containing methyl prednisolone IP may be an excellent formulation to treat oral ulcer caused by the consumption of. An attempt has been made to formulate new chewing gum device for metaclopramide in the form of tablet. The new drug delivery system was obtained , at room. Formulation and evaluation of medicated chewing gum as antiplaque and antibacterial agent. S Vasudha Lakshmi1, Hemant KS Yadav1*, KP Mahesh2, Swati.

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Urinary excretion profile showed that within the short span of time 1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.

Simple diffusion tormulation the medium causes the release of only a small percentage of the drug contained in the medicated chewing gum, while the delivery of the major part of the dose occurs during mastication. Analysis of vhewing revealed significant differences between subjects receiving F1 and F5 for antiplaque activity. Volume 7, Issue 4, July-August Drug release from a dosage form is the critical step in drug absorption and bioavailability, thus an experimental work has been designed to evaluate the efficiency of this kind of therapeutic system by verifying its capability to release the mmedicated dose and by assessing the delivery of Dolasetron for bypassing the hepatic first pass effect.

Downloads Download data is not yet available. As the proportion of gum base was increased, an increase in hardness of the chewing gum was observed.

Publication Policies and Ethics. Agri and Aquaculture Journals Dr. Home Publications Conferences Register Contact. Formulation and evaluation of medicated chewing gum of Metaclopramide.

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The new drug delivery system was obtained, at room temperature conventional pharmaceutical equipment. Journal of Current Pharma Research ; 4 4: The formulation, fofmulation contains highest concentration of chitosan, showed more in vitro release compared to other formulation.

The resulting chewing gum comprises a gum core combined with fillers, antioxidants, coloring agent and plasticizers, which provide smooth appearance and flexibility during storage and chewing.

Ezhumlai K, Rajalakshmi A. In the present study, an attempt has been made to formulate the chewing gum of Dolasetron.

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Naik H, Gupta S. An attempt has been made to formulate new chewing gum for Dolasetron. The prepared gums were evaluated for physical parameters, compatibility studies, drug content, moisture content, stability studies and in vitro drug-release testing. Simple diffusion into the medium causes the release of only a small percentage of the drug contained in the medicated chewing gum, while the delivery of the major part of the dose occurs during mastication.

Vol 7 No 4 Different formulations of chewing gum with varying concentration of plasticizers like glycerol and castor oil were formulated. Hot melt technique was used to prepare chewing gums.

Formulation And Evaluation Of Medicated Chewing Gum Of Metaclopramide |

A Modern Era of Drug Delivery, international research journal of pharmacy, ; 2 Chewing gumChitosanChlorhexidineDental Caries. Authors who publish with this journal agree to the following terms: Chlorohexidine Gluconate, Scholars Research Library, ; 2: Abstract An attempt has been made to formulate new chewing gum for Dolasetron. An attempt has been made to formulate new chewing gum device for metaclopramide in the form of tablet. Better consistency of formulation and faster release of drug in saliva was obtained with glycerol F IIIand Castor oil F II but castor oil shows optimum result against glycerol combination, which is formulation II.

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The new drug delivery system was obtained, at room temperature, by direct compression using conventional pharmaceutical equipment. Skip to formlation content Skip to main navigation menu Skip to site footer. The volunteers were visually examined for presence or absence of gingival erythema, gingival edema and gingival bleeding and the antibacterial activity was assessed by the reduction in bacterial count in the plaque samples. Authors are permitted and encouraged to post their work online e. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work e.

To carry out in vivo study on humans double-blind, crossover clinical trial was conducted on 18 adult volunteers from Department of Oral Medicine and Radiology, JSS Dental College, Mysore. Announcements Editorial Board Indexing Contact. Madan N, Rathnam A. Paresh is having 3 International review articles and He is attended 1 National conferences in Solan H. The dose of chlorhexidine can be reduced significantly when used along with chitosan.

Chitosan containing chewing medicaated has a greater antibacterial effect compared with gums containing only chlorhexidine.

Chewing gum, chitosan, chlorhexidine, dental caries. In the present study, an attempt tormulation been made to formulate the chewing gum of Metaclopramide. The 5- Hydroxytrytryptamin Receptor Antagonist as Antiementis: Guidelines Upcoming Special Issues.