Waldenstrom macroglobulinemia is a chronic, slow-growing lymphoproliferative disorder. It usually affects older adults and is primarily found in the bone marrow . Waldenström macroglobulinemia (WM) is a distinct clinicopathologic entity demonstrating lymphoplasmacytic lymphoma (LPL) in the bone. Waldenström macroglobulinemia is often an indolent disorder, and many patients are candidates for observation with careful monitoring.
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Del 6q and Del 17p – Genetic alterations associated with clinical progression of the disease. Infobox medical condition new. Curr Treat Waaldenstrom Oncol. In the peripheral blood, plasmacytoid lymphocytes are sometimes observed, but leukemic symptoms are rarely observed. Serum protein electrophoresis results indicate evidence of a monoclonal spike but cannot establish the spike as IgM.
IgM monoclonal gammopathy that excludes chronic lymphocytic leukemia and Mantle cell lymphoma.
Detection of monoclonal gammopathy – homogeneous peak, high, narrow base, usually in the area of gamma globulins. Development of diagnostic criteria and identification of prognostic factors”.
Pulmonary manifestations of Waldenstrom macroglobulinemia. The infiltration of malignant cells in the central nervous system is responsible for a rare neurological disorder called Bing-Neel syndrome.
Rare cancers Hematologic malignant neoplasms Vascular-related cutaneous conditions Lymphoma.
Crisp D, Pruzanski W. British Journal of Haematology. Flow cytometry may be used to examine markers on the cell surface or inside the lymphocytes.
There is no single accepted treatment for WM. How I treat Waldenstrom macroglobulinemia.
Waldenström’s macroglobulinemia – a review
How to cite this article. Vijay A, Gertz M. Creatinine is occasionally elevated and electrolytes are occasionally abnormal. This page was last edited on 20 Decemberat For diagnosis, a bone marrow biopsy is crucial to assess the extent of neoplastic infiltration, the infiltration pattern and cellular morphology.
Crit Rev Oncol Hematol. Fonseca R, Hayman S.
Another study showed the possibility of isotype switching occurring in vivo. Treatment of patients with asymptomatic WM does not improve the quality of life of patients, or increase their survival, being recommended, therefore, their follow-up. Apropos of a new case.
Table 1 presents waldnstrom diagnostic criteria for WM. High-resolution electrophoresis and serum and urine immunofixation are recommended to help identify and characterize the monoclonal IgM paraprotein.
Evaluation of thrombocytopenia and anemia, which is usually normocytic and normochromic Search autoimmune ejfermedad anemia. Pruzanski W, Shumak KH. LPL primarily involves the bone marrow, but the disease can reach the lymph nodes, spleen and liver, among other organs.
There are different treatment flowcharts: Prothrombin timeactivated partial thromboplastin timethrombin timeand fibrinogen tests should be performed. A report walcenstrom two cases. Guidelines on the management of Waldenstrom macroglobulinaemia.
The most frequent neurological disorder is a demyelinating distal symmetrical sensorimotor peripheral neuropathy, which manifests itself slowly and progressively, causing paresthesia and asthenia. Allogeneic stem cell transplantation can induce durable remissions for heavily pre-treated patients. D ICD – Four brothers with Waldenstrom’s macroglobulinemia. Recent studies have shown promising results with bortezomib, an inhibitor of proteasomes, and some patients respond to thalidomide.
However, the disease is incurable and the response enfwrmedad therapy is not always favorable. Although isotype switching is rarely seen in WM, according to some studies it is possible that it occurs ex vivo and in vivo.
When interpreting the results it is important to consider enfermedax some parameters could be altered because the monoclonal IgM may interfere in several measurements performed in automated analyzers, especially in the evaluation of HDL cholesterol, bilirubin, inorganic phosphate, LDL cholesterol, C-reactive protein, creatinine, glucose, urea, iron and calcium ions. WM is a rare disease, with only about 1, cases per year in the United States.
In patients requiring urgent control of the disease, plasmapheresis is indicated if they have clinical manifestations of moderate to severe hyperviscosity, cryoglobulinemia and cytopenias caused by the waldennstrom of the monoclonal IgM autoantibody.