Sandostatin Injection is available as: sterile 1-mL ampuls in 3 strengths, containing 50, mcg octreotide (as acetate), and sterile 5-mL multi-dose vials in 2. Sep 3, Octreotide Acetate (Sandostatin ®) – Intravenous (IV) Dilution. Octreotide (Sandostatin) is the longer acting synthetic analogue of the naturally In patients with cancer and inoperable bowel obstruction octreotide rapidly.
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No causal relationship to octreotide is suspected for these cases. Ultrasonic examination of the gallbladder before, and at about 6- to month intervals during Sandostatin therapy is therefore recommended. Step 4 Peel off outer syringe label and inspect syringe to ensure there are no visible particles. Oesophageal varices Since, following bleeding episodes from oesophageal varices, there is an increased risk for the development of insulin-dependent diabetes or for changes in insulin requirement in patients with pre-existing diabetes, an appropriate monitoring of blood glucose levels is mandatory.
SANDOSTATIN Dosage & Rx Info | Uses, Side Effects – MPR
Patients should be monitored periodically. Octreotide solutions for injection contain less than 1 mmol 23 mg of sodium per 1 ml of solution i.
Novartis Pharmaceuticals Corporation; Octreotide can help to further reduce gastric acid hypersecretion and improve symptoms, including diarrhoea, as it provides suppression doss elevated gastrin levels, in some patients.
Cholecystitis, biliary sludge, hyperbilirubinaemia. Some retardation of physiological growth was noted in the offspring of rats which was transient and attributable to GH inhibition brought about by excessive pharmacodynamic activity see section 4.
Multiple subcutaneous injections at the same site within short periods of time should be avoided. Patients should be monitored periodically Hyperglycemia and Hypoglycemia Blood glucose levels should be monitored Antidiabetic treatment should be adjusted accordingly Nutrition Vitamin B 12 levels: In rats receiving octreotide acetate at daily doses up to 1.
This medicinal product must not be mixed with other medicinal products except those mentioned in section 6. H01CB02 Octreotide is a synthetic octapeptide dossis of naturally occurring somatostatin with similar pharmacological effects, but with a considerably prolongedr octreotid of action.
Thus, the abovementioned observations were transient and considered to be the consequence of GH inhibition. Packs of 5 and 30 vials containing 1 ml of solution for injection. Use in children Experience with Sandostatin in children is limited.
Isolated cases of anaphylactic shock have been reported.
If gallstones do occur, they usually asymptomatic; symptomatic stones should be treated either by dissolution therapy with bile acids or by surgery.
Company contact details Hospira UK Ltd. To email a medicine you must sign up and log in. Since it cannot be excluded that octreotide may have this effect, other drugs mainly metabolised by CYP3A4 and which have a low therapeutic index should therefore octfeotide used with caution e.
Sandostatin 50 microgram/1 ml, solution for injection/infusion
Use in patients with impaired renal function Impaired renal function did not affect the total exposure AUC to octreotide administered as s. The dosage most generally effective is micrograms three times a octreotidd by s.
Intravenous infusion Parenteral drug products should be inspected visually for discoloration and particulate matter prior to administration. Continue typing to refine.
Octreotide is also indicated for acromegalic patients unfit or unwilling to undergo surgery, or in the interim period until radiotherapy becomes fully effective. Investigations Increased alkaline phosphatase levels, increased gamma glutamyl transferase octretide. It inhibits pathologically increased secretion of growth hormone GH and of peptides and serotonin produced within the GEP endocrine system. Monitor octreottide function, gallbladder, glucose, vitamin B Octreotide is to be used in association with specific treatment such as endoscopic sclerotherapy.
Sign Up Log In Cancel. Pregnancy There is a limited amount of data less than pregnancy outcomes from the use of octreotide in pregnant women, and in approximately one third of the cases the pregnancy outcomes are unknown. General disorders and administration site conditions.
Octreotide 100 micrograms/1ml Solution for Injection
In many cases, this is accompanied by a fall in plasma serotonin and reduced urinary excretion of 5-hydroxyindole acetic acid. Thrombocytopenia has been reported during post-marketing experience, particularly during treatment with Sandostatin i. Symptomatic control and reduction of growth hormone GH and IGF-1 plasma levels in patients with acromegaly who are inadequately controlled by surgery or radiotherapy. Repeat moderate shaking for another 30 seconds if the powder is not completely suspended.
General As GH-secreting pituitary tumours may sometimes expand, causing serious complications e. As GH-secreting pituitary tumours may sometimes expand, causing serious complications e. If no relevant reduction in GH levels and no improvement in clinical symptoms have been achieved within 3 months of starting treatment with Octreotide therapy should be discontinued.
In very rare instances, acute pancreatitis has been reported within the first hours or days of Octreotide s.
The only adverse event reported was mild hyperglycaemia. Step 5 Remove cap from syringe and screw syringe onto vial adapter Slowly push plunger all the way down to transfer all the diluent solution in disis vial.